ABSTRACT
Importance: Social isolation during outbreaks of epidemics always challenge psychological resilience profoundly. However, it still remains unclear how students’ mental health would be affected by strict o n-campus quarantine, which means students stayed at dormitories or on-campus for quarantine. We analyzed the data from one of the earliest universities releasing strict on-campus quarantine to prevent the Omicron spread-out in Shanghai, to evaluate the time course of the psychological resilience in the influence of an unexpected change in the living space in university students. Objectives: ： The campus was locked down on 9 th March. From 9 th to 23 rd , all students on campus were asked to stay in their dormitries, and teachers sent food supplies three times a day. From 24 th March to early April, students were gradually allowed to enter the campus for necessary activities. We quantify dynamic changes in depression severity during the campus locked down. Method: All participants were undergraduate or graduate students. The survey was released on 5th, April. All survey was dropped a public link on www.wjx.cn and administered from April 5th to 7th, 2022. Following the schedule of quarantine area, we assessed depressive symptoms in SJTU students from Period 1 (two weeks before 9 th , March), Period 2 (9 th to 23 rd , March), and Period 3 (24 th March to 5 th April). 274 students completed the online survey, and two incomplete data were excluded for further analysis. All these participants aged range from 18 to 25 years old and were quarantined in dormitories since 9 th March 2022. Findings: A remarkable increase in depression was observed in university students after stringent quarantine. The portion of students with depression started at 9.1% before quarantine and rapidly increased to 36.1% right after quarantine. No more increase in depressive symptoms was observed with time though quarantine was ongoing, which can be predicted by the food supplement satisfaction and the duration of physical fitness per day. Interestingly, the impact of a sudden change in living space on the psychological resilence was more evident in students who have a romatic relationship than singles.
ABSTRACT
In the global efforts to combat Covid-19, researchers have increasingly recognized the profound impacts of society lockdown on population mental health. However, the fine temporal evolution of negative psychological consequences induced by lockdowns remains poorly understood. Here we report a rapid and systematic increase in depression due to the Shanghai Covid lockdown in March 2022. Measured by Beck Depression Inventory-2, 10% of the participants experienced at least mild depression before the official citywide lockdown started, and two and four weeks later this number increased to 21% and 36 %, respectively. Regression analyses show that lockdown duration and physical restriction jointly contribute to worsening depression. Furthermore, the time of sleep and social communication during the lockdown are associated with the severity of depression symptoms. These results highlight the fast development of depression during lockdowns and call for special attention to early psychological interventions once a lockdown is initiated.
Subject(s)
COVID-19ABSTRACT
There is no specific medicine recommended during the emergency of 2019-nCov has been an outbreak and in COVID-19 outbreak zone where the climate is mildly warm, we highly recommend to use the elderberry in order to protect your health and there are 2 species of elderberries: one, Sambucus adnata, is termed the “blood-red herb-elderberry” by local residents as the roots, rhizomes, and branches exude red-juice when broken; the second, named S. javanica or S. chinensis is commonly called the “herb-elderberry”. This therapeutics paper aims to publish our monography on the elderberry, as no English literature references are present in China because most Chinese horticulturists and farmers consider the elderberry a wild plant. It is regarded as a plant of little value due to its abundance and ease of harvest. Our article contains details of the Sambucus species groups, including the botanical names, Chinese common names, geographic distributions, medical uses.
Subject(s)
COVID-19ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing coronavirus disease 2019 (COVID-19) pandemic. Understanding the influence of mutations in the SARS-CoV-2 gene on clinical outcomes and related factors is critical for treatment and prevention. Here, we analyzed 209,551 high-coverage complete virus sequences and 321 RNA-seq samples to mine the mutations associated with clinical outcome in the SARS-CoV-2 genome. Several important hotspot variants were found to be associated with severe clinical outcomes. Q57H variant in ORF3a protein were found to be associated with higher mortality rate, and was high proportion in severe cases (39.36%) and 501Y.V2 strains (100%) but poorly proportional to asymptomatic cases (10.04%). T265I could change nsp2 structure and mitochondrial permeability, and evidently higher in severe cases (20.12%) and 501Y.V2 strains (100%) but lower in asymptomatic cases (1.43%). Additionally, R203K and G204R could decrease the flexibility and immunogenic property of N protein with high frequency among severe cases, VUI 202012/01 and 484K.V2 strains. Interestingly, the SARS-CoV-2 genome was more susceptible to mutation because of the high frequency of nt14408 mutation (which located in RNA polymerase) and the high expression levels of ADAR and APOBEC in severe clinical outcomes. In conclusion, several important mutation hotspots in the SARS-CoV-2 genome associated with clinical outcomes was found in our study, and that might correlate with different SARS-CoV-2 mortality rates.
Subject(s)
Coronavirus Infections , COVID-19ABSTRACT
We report a critically ill pregnant woman in the third trimester with severe pneumonia due to COVID-19 who presented to Xiaolan People's Hospital of Zhongshan in February 2020. The 32-year-old patient was admitted at 35 +2 gestational weeks with a 4-day history of a sore throat and a fever for three hours. The patient had been to Xiaogan City, Hubei Province, and the symptoms occurred during a period of self-isolation after back home. The condition of the patient deteriorated rapidly, with left-sided chest and back pain, shortness of breath, dizziness, progressing to respiratory failure and septic shock 7 hours after her admission. In view of her critical condition and a history of two previous cesarean sections, an emergency cesarean section was performed. Blood gas analysis of the mother before the operation suggested respiratory failure, respiratory acidosis, and metabolic acidosis. During the operation, a baby boy was born. The Apgar score of the boy, birth weight of 2 700 g, was one at 1, 5 and 10 minutes despite the resuscitation efforts. The neonate died after withdrawing treatment. The patient was treated with tracheal intubation ventilator and other supportive treatments after the operation. The result of the new coronavirus nucleic acid test, taken on admission, but which was reported after delivery, was positive. The patient was transferred to the designated hospital for further treatment and was recovering with the withdrawal of extracorporeal membrane oxygenation and ventilation support at 26 and 36 days after surgery, respectively.